Structure of PDB 8jfl Chain E Binding Site BS01

Receptor Information
>8jfl Chain E (length=970) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSIL
AVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESF
KYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTASG
LHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASSVGMA
KAALEALLADEVQHCQSILNSLLPRASTSKEVDASLLSVVSFPAFAVEDS
QLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFEN
IECEWPLFWTYFILDGVFSGNAEQVQEYKEALEAVLKNGVPLLPELYSVP
PDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFLAPGEIDPL
NRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPA
RILSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFTFTPQFID
QQQFYLALDNKMIVEMLRTDLSYLCSRWRMTGQPTITFPISHSMLDEDGT
SLNSSILAALRKMQDGYFGGARVQTGKLSEFLTTSCCTHLSFMDPGSGEV
DFKALVLQLKEQADILYMLYTMKGPDWTELYNERSATVRELLTELYGKVG
EIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHLTVGLPPEPREKTIS
APLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAEMFRL
RIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHHILSGKEFQ
GQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSVEGFVLPSSTTREMT
PGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIEIHSIGSIIAV
EKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPSGRFGTMT
YLSKAAATYVQEFLPHSICA
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain8jfl Chain E Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jfl Architecture and activation of human muscle phosphorylase kinase
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K1081 L1137 A1207 A1208 V1211 S1218 C1220
Binding residue
(residue number reindexed from 1)		K830 L886 A956 A957 V960 S967 C969
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0045819 positive regulation of glycogen catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005964 phosphorylase kinase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jfl, PDBe:8jfl, PDBj:8jfl
PDBsum8jfl
PubMed38548794
UniProtP46020|KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Gene Name=PHKA1)

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