Structure of PDB 8iuo Chain E Binding Site BS01

Receptor Information
>8iuo Chain E (length=362) Species: 208893 (Human respiratory syncytial virus A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGM
LLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTH
RQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYR
HDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGL
LPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNA
YGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGF
YHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAA
KAYAEQLKENGV
Ligand information
>8iuo Chain F (length=35) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8iuo Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		K170 A181 R184 R185 N188 R238 I242 N249 G254 V256 S313 T315 E336 Y337 R338
Binding residue
(residue number reindexed from 1)		K170 A181 R184 R185 N188 R238 I242 N249 G254 V256 S313 T315 E336 Y337 R338
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0019013 viral nucleocapsid
GO:0019029 helical viral capsid
GO:0030430 host cell cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuo, PDBe:8iuo, PDBj:8iuo
PDBsum8iuo
PubMed37607909
UniProtA0A2H4WKL8

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