Structure of PDB 8ihm Chain E Binding Site BS01

Receptor Information
>8ihm Chain E (length=100) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRF
QSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>8ihm Chain I (length=158) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttactggccgccctggagaatcccggtgccgaggccgctcaattggtcgt
agacagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttt
taaccgccaaggggattactccctagtctccaggcacgtgtcagatatat
acatcctg
Receptor-Ligand Complex Structure
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PDB8ihm Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Resolution3.58 Å
Binding residue
(original residue number in PDB)		R40 Y41 G44 V46 K64 L65 R69
Binding residue
(residue number reindexed from 1)		R6 Y7 G10 V12 K30 L31 R35
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8ihm, PDBe:8ihm, PDBj:8ihm
PDBsum8ihm
PubMed37845487
UniProtP84233|H32_XENLA Histone H3.2

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