Structure of PDB 8igv Chain E Binding Site BS01

Receptor Information
>8igv Chain E (length=440) Species: 768486 (Enterococcus hirae ATCC 9790) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKEYRTIKEVVGPLMAVEKVSGVKYEELIEVRMQNGEIRRGQVLEVQEDK
AMVQIFEGTSGINLKNSSVRFLGHPLQLGVSEDMIGRVFDGLGRPKDNGP
EILPEKYLDINGEVINPIARDYPDEFIQTGISAIDHLNTLVRGQKLPVFG
PPGAGKSALAAQIARQATVLDSSDDFAVVFAAIGITFEEAEFFMEDFRQT
GAIDRSVMFMNLANDPAIERIATPRMALTAAEYLAYEKGMHVLVIMEDMT
NYAEALREISAARREVPGRRGYPGYLYTNLATLFERAGRIRGLKGSVTQI
PILTMPEDDKTHPIPDLTGYITEGQIILTRELYKSGISPPIDVLPSLSRL
KDKGTGAGKTREDHAATMNQLFAAYAQGKQAKELSDIDKIYAKFAERFEN
EYVNQGFYTNRTITETLDLGWELLAMLPRTELKRIKDDLL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain8igv Chain E Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8igv Design of allosteric sites into rotary motor V 1 -ATPase by restoring lost function of pseudo-active sites.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		G154 A155 G156 K157 S158
Binding residue
(residue number reindexed from 1)		G153 A154 G155 K156 S157
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process
GO:0006814 sodium ion transport
GO:0042777 proton motive force-driven plasma membrane ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport

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Molecular Function
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Biological Process
External links
PDB RCSB:8igv, PDBe:8igv, PDBj:8igv
PDBsum8igv
PubMed37414880
UniProtQ08637|NTPB_ENTHA V-type sodium ATPase subunit B (Gene Name=ntpB)

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