Structure of PDB 8iaj Chain E Binding Site BS01

Receptor Information

>8iaj Chain E (length=495) Species: 3702,559292

GHFFVEGLLGVVIIILLTRKSYKPPKRPLTEQEIDELCDEWVPEPLVDPS
ATDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLS
ATEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSV
LYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHN
DMNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKL
KNKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALG
STGGFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDA
VQTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFG
YTCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLITR
NTIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACCQ

Ligand information

• Ligand ID: PLP
• InChI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
  OpenEye OEToolkits 1.5.0: Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
  ACDLabs 10.04: O=P(O)(O)OCc1cnc(c(O)c1C=O)C
• Formula: C8 H10 N O6 P
• Name: PYRIDOXAL-5'-PHOSPHATE;
  VITAMIN B6 Phosphate
• ChEMBL: CHEMBL82202
• DrugBank: DB00114
• ZINC: ZINC000001532514
• PDB chain: 8iaj Chain F Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8iaj Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): S385 A386
• Binding residue (residue number reindexed from 1): S326 A327
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.50: serine C-palmitoyltransferase.

Gene Ontology

Molecular Function

• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009058 biosynthetic process

External links

• PDB: RCSB:8iaj, PDBe:8iaj, PDBj:8iaj
• PDBsum: 8iaj
• PubMed: 38285738
• UniProt: P25045|SPTC1_YEAST Serine palmitoyltransferase 1 (Gene Name=LCB1);
  Q94IB8|SPTC1_ARATH Long chain base biosynthesis protein 1 (Gene Name=LCB1)