Structure of PDB 8gpn Chain E Binding Site BS01

Receptor Information
>8gpn Chain E (length=98) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>8gpn Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tggagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcacatatatacatcctgt
Receptor-Ligand Complex Structure
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PDB8gpn Menin "reads" H3K79me2 mark in a nucleosomal context.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R40 Y41 P43 V46 A47 R52 K64 P66 R69
Binding residue
(residue number reindexed from 1)		R4 Y5 P7 V10 A11 R16 K28 P30 R33
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:8gpn, PDBe:8gpn, PDBj:8gpn
PDBsum8gpn
PubMed36795828
UniProtP84233|H32_XENLA Histone H3.2

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