Structure of PDB 8gae Chain E Binding Site BS01

Receptor Information
>8gae Chain E (length=459) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAY
LRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETV
VKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTI
EDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSK
LSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDF
VDRGSFSVEVILTLFGFKLLYPDHFHLLRGNAETDNMNQIYGFEGEVKAK
YTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERN
RQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDY
IIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQ
FHQFTAVPH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8gae Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gae Hsp90 provides a platform for kinase dephosphorylation by PP5.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D242 H244 D271 Y451
Binding residue
(residue number reindexed from 1)		D220 H222 D249 Y429
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017018 myosin phosphatase activity
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006351 DNA-templated transcription
GO:0006470 protein dephosphorylation
GO:0010288 response to lead ion
GO:0035970 peptidyl-threonine dephosphorylation
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0043278 response to morphine
GO:0070262 peptidyl-serine dephosphorylation
GO:1904550 response to arachidonate
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle
GO:0101031 protein folding chaperone complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gae, PDBe:8gae, PDBj:8gae
PDBsum8gae
PubMed37069154
UniProtP53041|PPP5_HUMAN Serine/threonine-protein phosphatase 5 (Gene Name=PPP5C)

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