Structure of PDB 8fjl Chain E Binding Site BS01

Receptor Information
>8fjl Chain E (length=1106) Species: 185783 (Golden shiner reovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTPIVNPSSYVCNVCNARFSTMSALSEHLRSDHRDDASTLLATPMINNAI
RSFLTAWDGIRILSPDVSSKHLSAYLDSAVANGPELIVEDTGLCTSFMLL
DNIPSAHLTKELIGFTWFMQMYQMTPPLPEGAVNRIVCMTNWASLGDEGR
GLEVRLPPPTDSSVHAYKTVLSRGYIDNAQFNPLALRSNVLLMLLQFTLS
NLKINKSSTFTSDVTTITSGRMIRAFEGRPELLALAYPGRAVLPTQTKNA
QFLSTAIADRIGRLDRANLIGGEVSAMVECMELCDALTLHIRETYVMLLR
SMHQDPTQIVQIVNECANNLLNSTIPISLRPTILCPWFASSEDLRLQQVM
HLVNISSNTAAALPLVEALSTLLRSVTPLVLDPTVLTNAITTISESTTQT
ISPISEILRLLQPMGNDYAAFWKCIASWAYNGLVTTVLSEDAFPDSSQSI
THLPSMWKCLFLTLAGPMTSDPHSPVKVFMALANLLAQPEPIAIGVPGMH
QTTPASQFSHPGVWPPGFLNPQLINPQQAPLLRAFAEHIRANWPQPSEFG
YGSTLQGSANLFIPPNRMVYPWPNQPLPRLTVAPTYDSAMSNWISTTIAF
FIRVVNSVNMTATVNDLTRRTMTGVMTAMRQVKTMTPFYIQHMCPTELSV
LASVTVTPPFQVPFTRLVQNDVITNVLVARVDPAQRGDAAVDIRATHATF
AAALPVDPAAIVVAMLCGQTETNLIPSHHYGKAFAPLFASNAMFTRNQRA
VITREAFVCARSAVAQCQDAGFLVPRPLDALRQFDVTSAAAAEIMHAVND
AFKTAFDLDGALLDGLALYGDPRIADLSAAYLQYGGNVVREHVPPGPSHI
HRTLQQVESTFMAEMNLFNVARGNLYLVQTATNGNWSPMAPVAAPPFVRG
GPNVRVVGRFGTIVPRPDGLEPQLIDDGNVPRDIAGDWVYPSDVLQVSVA
VFCDYVWPMVKAGRTRVLVELGHYVYTLHYYDPQISLDEAPILEEWLSKI
NPAGIPPVPFCIPIPQVYPCITARRVHYAFTSENNNDSLFSTNAASIDTA
FGENAAVSPLRWPGLVDPNYRVGTNDLPNRITLYNSLYRYNFTYPTLDGI
MYVRSA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fjl Chain E Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fjl Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation.
Resolution3.27 Å
Binding residue
(original residue number in PDB)		C119 C122 H135 H140
Binding residue
(residue number reindexed from 1)		C12 C15 H28 H33
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0039616 T=2 icosahedral viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fjl, PDBe:8fjl, PDBj:8fjl
PDBsum8fjl
PubMed36856784
UniProtQ8JU60|CAPSD_AQRVC Major inner capsid protein VP3 (Gene Name=S3)

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