Structure of PDB 8fe7 Chain E Binding Site BS01

Receptor Information

>8fe7 Chain E (length=705) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKALNMPVIPMNTIAE
AVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQ
YGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEP
NIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGM
DVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLG
TDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPD
HMIKP

Ligand information

>8fe7 Chain F (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

QRPTQPVYQIQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fe7 Crystal structure of human O-GlcNAc transferase (OGT) in complex with an exosite-binding peptide (SMG9) and UDP-GlcNAc
Resolution	2.98 Å
Binding residue (original residue number in PDB)	K714 I777 I780 N781 G783 S823 G826 L827
Binding residue (residue number reindexed from 1)	K403 I453 I456 N457 G459 S499 G502 L503

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:8fe7, PDBe:8fe7, PDBj:8fe7
PDBsum	8fe7
PubMed	37653170
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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