Structure of PDB 8eup Chain E Binding Site BS01

Receptor Information
>8eup Chain E (length=170) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYYPAYRENVPKKARKAVRPTKLRASLAPGTVCILLAGRFRGKRVVVLSQ
LEDTLVVTGPYKVNGVPIRRVNHRYVIATSAPKIDVSGVSVEKFTKAYFA
KQKRSGPVKKDEAFFAENAPKNALPAERIADQKAVDAKLLPAIKAIPNMK
EYLAASFALSNGDRPHLMKF
Ligand information
>8eup Chain 1 (length=1422) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagc
uaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaug
aaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggg
aagcauuggaaaucagucuuaccugggugagaucaguagucucucgagac
uaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaa
aagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacu
ggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaa
uggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguu
ugggugaugaaaacccauccgcgaaggugggaacgcccuuguggcgugca
ccaucgaagagcauagcuguugggacccgaaagauggugaaccaucuagu
agcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuua
uguguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggc
gaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucau
cagaaagguguuaguucauaugaacuagcccugggcgcuuaagcguacua
cccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggca
ggcguggagguuugugacgaagccuugggcgugagccugggucgaacagc
cucuagugcagaucuugguggaaguagcuagaucuagcgaaaccacagcc
uggggaacgggccaggcaaucgucgcaaugguaauucaacuuaguacgag
aggaaccguugauucagaucauugguauuugcggccgcggagcuaucauc
ugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcg
acgauuauguauaaaaauagagguaggcuacucuccuguaucguagaaga
ugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaau
uccaugaauccauugcauacgacuuuaauguggaacgggguauugagauu
aagccuuuguucccaagauuug
.........................<<<<<........>>>>>.......
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<...<.
......<<.<<<<<<<.......>>>>>>>.>>.......>.....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>
..................................<<....>>........
.......<<<<....>>>>...............................
...<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>
>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<....
......<<<<<.................>>>>>.........>>>>>.>>
>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..
.<<<<.......>>>>...>>>...<<<<<..<<<<<.....>>>>>...
>>>>>.....>>>>>>.>>>>>>..<<.<..<<<<<<<..>>>>>>>...
..>.>>..<<<<<<......<<..>>..<<<<<<<<<....<<<.<<<<<
<..>>>>>>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>
....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<....
.<<..<<<.<<<<<<<<<..>>>>>>>>>>>>.))).>>...>>>>>>.>
>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>
>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>
>>>>>........>>>>>><<.....<<<<<..>>>>>....>>....<<
<<<........>>>>>...<<<<<<<..<<<<...<<<<<..........
.......>>>>>..<<<<<...<<<<....<<<..>>>...>>>>..>>>
>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>
>>>>......<<.......<<<<..<..>..>>>>....>>........<
<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.....
.....<<<<<.<.............>.....<<<<<<<<<.<<<..>>>.
...>>>>.>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eup Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K26 Y27 Y28 R32 N34 V35 K37 A39 R40 K41 A42 R44 T46 A62 R64 T79 Y86 K87 V88 N89 G90 R94 R95 N97 H98 R99 Y100 F124 A125 K126 Q127 P132 N147 L149 R153 E176 A179 S181 S185 N186
Binding residue
(residue number reindexed from 1)		K1 Y2 Y3 R7 N9 V10 K12 A14 R15 K16 A17 R19 T21 A37 R39 T54 Y61 K62 V63 N64 G65 R69 R70 N72 H73 R74 Y75 F99 A100 K101 Q102 P107 N122 L124 R128 E151 A154 S156 S160 N161
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8eup, PDBe:8eup, PDBj:8eup
PDBsum8eup
PubMed36423630
UniProtP79071|RL6_SCHPO Large ribosomal subunit protein eL6 (Gene Name=rpl6)

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