Structure of PDB 8eik Chain E Binding Site BS01

Receptor Information
>8eik Chain E (length=378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVC
CEGRELLLCSNTSCCRCFCVECLEVLVGQRCHGVLRRRKDWNVRLQAFFT
SDYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASE
VCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCGLYE
GTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLEC
NPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIA
KLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGA
RQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
>8eik Chain F (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EGTGRLFFEFYHLLGDKRDISRFL
Receptor-Ligand Complex Structure
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PDB8eik Cryo-EM structure of human DNMT3B homo-hexamer
Resolution3.19 Å
Binding residue
(original residue number in PDB)		H677 F713
Binding residue
(residue number reindexed from 1)		H211 F247
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:8eik, PDBe:8eik, PDBj:8eik
PDBsum8eik
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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