Structure of PDB 8eho Chain E Binding Site BS01

Receptor Information
>8eho Chain E (length=166) Species: 28344 (Porcine reproductive and respiratory syndrome virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPTCGITTYSPPTDGSCGWHVLAAIMNRMINGDFTSPLTQYNRPEDDWAS
DYDLVQAIQCLQLPATVVRNRACPNAKYLIKLNGVHWEVEVRSGMAPRSL
PRECVVGVCSEGCVAPPYPADGLPKRALEALASAYRLPSDCVSSGIADFL
ANPPPQEFWTLDKMLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8eho Chain E Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8eho Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		C485 C516 C521 C525
Binding residue
(residue number reindexed from 1)		C73 C104 C109 C113
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Biological Process
GO:0016032 viral process
GO:0019082 viral protein processing

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Biological Process
External links
PDB RCSB:8eho, PDBe:8eho, PDBj:8eho
PDBsum8eho
PubMed38096325
UniProtW0NX70

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