Structure of PDB 8ecy Chain E Binding Site BS01

Receptor Information
>8ecy Chain E (length=366) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVTYTARVAKARFGGFSKLLLLWRGSIYKLLWRELLCFLGLFMALSAAYR
FVLTEEQKRYFEKLVLYCDRYASLIPVSFVLGFYVTLVVHRWWNQYLSMP
LTDALMCVVVGTVHGHDERGRLYRRTLMRYAGLSGVLILRSVSTAVFKRF
PTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFCNLAAQARREGRI
RDNGAFKLLLEELNVFRSKCGMLFHYDWISVPLVYTQVVTIAVYSYFLAC
LIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGED
DDDFETNFLIDRCFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAAT
AFLMQQPSFQGSTFDI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8ecy Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ecy Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q293 N296 D301 D304
Binding residue
(residue number reindexed from 1)		Q292 N295 D300 D303
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity

View graph for
Molecular Function
External links
PDB RCSB:8ecy, PDBe:8ecy, PDBj:8ecy
PDBsum8ecy
PubMed36289327
UniProtE1BF86|BEST2_BOVIN Bestrophin-2 (Gene Name=BEST2)

[Back to BioLiP]