Structure of PDB 8ech Chain E Binding Site BS01

Receptor Information

>8ech Chain E (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

Ligand information

>8ech Chain C (length=11) Species: 11084 (Tick-borne encephalitis virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RKIKRQKRGKR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ech Structure and biological functions of tick-borne encephalitis virus capsid protein
Resolution	2.05 Å
Binding residue (original residue number in PDB)	S105 W142 N146 A148 S149 G150 T155 Q181 W184 N188 D192 N228 W231 R238 V321 T322 G323 K353 W357 N361 S406
Binding residue (residue number reindexed from 1)	S34 W71 N75 A77 S78 G79 T84 Q110 W113 N117 D121 N157 W160 R167 V250 T251 G252 K282 W286 N290 S335

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ech, PDBe:8ech, PDBj:8ech
PDBsum	8ech
PubMed
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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