Structure of PDB 8dh5 Chain E Binding Site BS01

Receptor Information
>8dh5 Chain E (length=803) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFR
KMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFIKPEAVAYITIKT
TLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHFKKNVEEQLN
KRVGHVYKKAFMQVVEADMLSKGLDSIHVGVRCIEMLIESTETIELAPEY
AEAIATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTH
SKKALMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVE
DIPAIWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMD
WRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVD
KVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGV
QHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIY
GIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQWL
AYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPN
QAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRK
RCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRDSEIDAHKQESGIAP
NFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAVRE
TMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNLNLRDILESDF
AFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh5 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 R423 Y427 T636 Y639 G640 S641 F644 G645 Y739 H772 P780
Binding residue
(residue number reindexed from 1)		R48 R55 E61 R248 R352 Y356 T565 Y568 G569 S570 F573 G574 Y668 H692 P700
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh5, PDBe:8dh5, PDBj:8dh5
PDBsum8dh5
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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