Structure of PDB 8dh3 Chain E Binding Site BS01

Receptor Information
>8dh3 Chain E (length=825) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRK
MFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEPTAFQFLQEIKPE
AVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHF
KKNVEEQLNKRVGHVYKKAFMQVVEADMLSSWHKEDSIHVGVRCIEMLIE
STGMVSLHETIELAPEYAEAIATRAGALAGISPMFQPCVVPPKPWTGITG
GGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNTAWKINKK
VLAVANVITKWKHCPVEDIPAIEALTAWKRAAAAVYRKDKARKSRRISLE
FMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTKGLLTLAKG
KPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMACAKSPLEN
TWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCSGIQHFSAM
LRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTDNEVVTVTD
ENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQ
VLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWL
KSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNL
MFLGQFRDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFA
LIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQL
DKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh3 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 R423 Y427 M431 T636 Y639 G640 S641 F644 Q649 K713 Y739 H772 P780 H784
Binding residue
(residue number reindexed from 1)		R47 R54 E60 R265 R374 Y378 M382 T587 Y590 G591 S592 F595 Q600 K664 Y690 H714 P722 H726
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh3, PDBe:8dh3, PDBj:8dh3
PDBsum8dh3
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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