Structure of PDB 8dh1 Chain E Binding Site BS01

Receptor Information
>8dh1 Chain E (length=785) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKAGEVADN
AAAKPLITTLLPKMIARINDIKPEAVAYITIKTTLACLTVASAIGRAIED
EARFGRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLG
GEAWSSWHKEDSIHVGVRCIEMLIESTIELAPEYAEAIATRAGALAGISP
MFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEV
YKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIWKRAAAAVYRK
DKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGN
DMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHE
NIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFD
GSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAI
NGTDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTL
AYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSV
TVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQ
EYKKPIQTRLNLMFLGQDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWA
HEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQ
FADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8dh1 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R50 R57 R298 H300 W422 R423 Y427 R632 Y639 S641 F644 G645 Q649 E652 Y739 H772 P780
Binding residue
(residue number reindexed from 1)		R33 R40 R232 H234 W335 R336 Y340 R545 Y552 S554 F557 G558 Q562 E565 Y652 H674 P682
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8dh1, PDBe:8dh1, PDBj:8dh1
PDBsum8dh1
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

[Back to BioLiP]