Structure of PDB 8d67 Chain E Binding Site BS01

Receptor Information
>8d67 Chain E (length=307) Species: 204038 (Dickeya dadantii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVDVSVSIFINKIYGVNTLEQTYKVDGYIVAQWTGKPRKTPGDKPLIVEN
TQIERWINNGLWVPALEFINVVGSPDTGNKRLMLFPDGRVIYNARFLGSF
SNDMDFRLFPFDRQQFVLELEPFSYNNQQLRFSDIQVYTENIDNEEIDEW
WIRGKASTHISDIRYDHLSSVQPNQNEFSRITVRIDAVRNPSYYLWSFIL
PLGLIIAASWSVFWLESFSERLQTSFTLMLTVVAYAFYTSNILPRLPYTT
YIDQMIIAGYGSIFAAILLIIFAHHRQANGVEDDLLIQRCRLAFPLGFLA
IGCVLVI
Ligand information
Ligand IDDHL
InChIInChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChIKeyUFULAYFCSOUIOV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04SCCN
OpenEye OEToolkits 1.5.0C(CS)N
CACTVS 3.341NCCS
FormulaC2 H7 N S
Name2-AMINO-ETHANETHIOL;
2,3-DESHYDROLANTHIONINE
ChEMBLCHEMBL602
DrugBankDB00847
ZINCZINC000008034121
PDB chain8d67 Chain E Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8d67 Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		E77 E131 H177
Binding residue
(residue number reindexed from 1)		E67 E121 H167
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0016020 membrane
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d67, PDBe:8d67, PDBj:8d67
PDBsum8d67
PubMed36385237
UniProtE0SJQ4

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