Structure of PDB 8d0k Chain E Binding Site BS01

Receptor Information

>8d0k Chain E (length=431) Species: 9606 (Homo sapiens)

DQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVK
GTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEE
LRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQE
IVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIV
AIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSGNVGKISLD
QIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQAL
QFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKIILSN
PPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVAC
QKYFEMIHNVDDCGFSLNHPNQFFCESQRIL

Ligand information

>8d0k Chain H (length=20)

tagggttagggttagggtta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d0k Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
• Resolution: 4.27 Å
• Binding residue (original residue number in PDB): Y347 H351 E356 G357 K358
• Binding residue (residue number reindexed from 1): Y323 H327 E332 G333 K334

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding
• GO:0071667 DNA/RNA hybrid binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006269 DNA replication, synthesis of primer
• GO:0006270 DNA replication initiation
• GO:1903934 positive regulation of DNA primase activity

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005658 alpha DNA polymerase:primase complex
• GO:1990077 primosome complex

External links

• PDB: RCSB:8d0k, PDBe:8d0k, PDBj:8d0k
• PDBsum: 8d0k
• PubMed: 35830881
• UniProt: P49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)