Structure of PDB 8cqw Chain E Binding Site BS01

Receptor Information
>8cqw Chain E (length=217) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGWTPVTKLGRLVKAGKITSVEQIYLHSLPVKEYQIIDLLLPDLKDDVMK
IRSVQKQTRAGQRTRMKAVVVIGDSNGHVGLGIKTAKEVASAIKAAIVIA
KLSIIPIRRGYWGSNLGQPHSLPCKVTGKCGSVAVRLIPAPRGKGIVASP
VVKRLMQLAGVEDVYTSSSGSTRTTENTLKAAFAAIGNTYSFLTPNLWAE
TPLAASPLEVYAEEAAA
Ligand information
>8cqw Chain B (length=1741) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguacccuacuuggauaaccguggu
aauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggaugu
auuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaau
aacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuuc
ugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacg
gguaacggggaauaaggguucgauuccggagagggagccugagaaacggc
uaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacac
ggggagguagugacaauaaauaacgauacagggcccuuuugggucuugua
auuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggca
agucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaa
aguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccg
ggcguacuggacccagccgagccuuuccuucuggguagccgaaccaggac
uuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauau
auuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuu
cuaggaccaucguaaugauuaauagggacggucggggguaucaguauuca
guugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaa
gcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucg
aagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagg
gaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaauca
aagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaagg
aauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacu
caacacggggaaacucaccagguccagacacaauaaggauugacagauug
agagcucuuucuugauuuugugggugguggugcauggccguucuuaguug
guggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccua
cuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacu
aucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcc
cuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagua
uaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcug
gggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagc
gcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgc
ccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuua
uucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaag
ucguaacaagguuuccguaggugaaccugcggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<............<<.....<..<<..
.....>>..>......>>........<<<<<..<<....>>..>>>>><.
..<<<<<<.......((((((.<<<....>>>..............>>>>
>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>
>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>
>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>
>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>
>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>
.>>>......<<..<...........>..>>.........<<<<<((...
...<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.
........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.....
..............>>>>>>>>>>.....<<<<...........>>>>..
..<<<<<.<<.......<<...<.......>..<<<....>>>....>>.
.....>>.>>..>>>.........<<<..<<<<<<<<......)))))).
..>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<
<<.<...<<<......>>>......>.>>>>>>..>>.......<<....
>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<.
..<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<
..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>.
..>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]
].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<...
.....>>..........<<<<<......<<<<<........<<.<<<...
.....>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.
<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..
<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....
<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>
>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<..
....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......
<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<
<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<.
.<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<...
.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>
.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cqw Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.05 Å
Binding residue
(original residue number in PDB)
R79 V81 Q82 K83 Q84 T85 R86 A87 Q89 R90 K94 K111 T154 K156 C157 G158 S159 R163 K171 V174 A175 S176 Y192 T193 S195 T199 R200 T201 N204 K207
Binding residue
(residue number reindexed from 1)
R52 V54 Q55 K56 Q57 T58 R59 A60 Q62 R63 K67 K84 T127 K129 C130 G131 S132 R136 K144 V147 A148 S149 Y165 T166 S168 T172 R173 T174 N177 K180
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