Structure of PDB 8cbk Chain E Binding Site BS01

Receptor Information
>8cbk Chain E (length=470) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSL
LAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPR
GYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVN
TAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNN
QLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLS
PEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGL
NVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEME
EVQKQASCFFADDISEDAPFLLYATLHSGNHCRFITRDLMRDHKACLPDA
KTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYD
EDLVERCSCEVPTKWLCLHQ
Ligand information
>8cbk Chain T (length=93) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcuuguaaauauaguuuaaaaacaucagauugugaaucugacaacagag
gcuuaccccuuauuuaccgagaaagccaugcauggcuuucuca
.....<<<<<<<..<<<<..>>>>.<<<<<.......>>>>>....<<.<
<....>>.>>>>>>>>>.<<<<<<<<<<<..>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8cbk Structural basis for human mitochondrial tRNA maturation.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		K244 K245 N412 K415 F417 P418 K419 H447 R450 R498 D499 L500 R502 R531 F532 P533
Binding residue
(residue number reindexed from 1)		K133 K134 N301 K304 F306 P307 K308 H336 R339 R387 D388 L389 R391 R420 F421 P422
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0004526 ribonuclease P activity
GO:0046872 metal ion binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cbk, PDBe:8cbk, PDBj:8cbk
PDBsum8cbk
PubMed38824131
UniProtO15091|MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (Gene Name=PRORP)

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