Structure of PDB 8bzl Chain E Binding Site BS01

Receptor Information

>8bzl Chain E (length=228) Species: 9606 (Homo sapiens)

NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAA
HQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRL
VSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRA
MSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTK
NVSIGIVGKDLEFTIYDDDDVSPFLEGL

Ligand information

>8bzl Chain f (length=3) Species: 32630 (synthetic construct)

YYS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bzl Peptidic, Blm10-based activators of human 20S proteasome in vitro and in cellulo enhance degradation of proteins connected with neurodegeneration.
• Resolution: 2.14 Å
• Binding residue (original residue number in PDB): A28 S33 K62 I74 G76 T78
• Binding residue (residue number reindexed from 1): A25 S30 K54 I66 G68 T70

Gene Ontology

Molecular Function

• GO:0001530 lipopolysaccharide binding
• GO:0005515 protein binding

Biological Process

• GO:0002376 immune system process
• GO:0002862 negative regulation of inflammatory response to antigenic stimulus
• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005813 centrosome
• GO:0005829 cytosol
• GO:0005839 proteasome core complex
• GO:0019773 proteasome core complex, alpha-subunit complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8bzl, PDBe:8bzl, PDBj:8bzl
• PDBsum: 8bzl
• UniProt: P25786|PSA1_HUMAN Proteasome subunit alpha type-1 (Gene Name=PSMA1)