Structure of PDB 8ab7 Chain E Binding Site BS01

Receptor Information

>8ab7 Chain E (length=186) Species: 4952 (Yarrowia lipolytica)

GKSTYKIPDFTPYLKKDRNTDANRLFSYFMIGSFGMLSAAGAKATVQDFL
SNMSASADVLAMAKVEVKLGAIPLGKNVIIKWRGKPIFIRHRTSEEIEEA
NEVNVATLRDPQTDDERVQKPEWLVMIGVCTHLGCVPIGEAGDFGGWFCP
CHGSHYDISGRIRRGPAPLNLEIPEYDFADAETLVI

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 8ab7 Chain E Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ab7 Analysis of the conformational heterogeneity of the Rieske iron-sulfur protein in complex III 2 by cryo-EM.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): C168 H170 L171 C187 H190 S192
• Binding residue (residue number reindexed from 1): C130 H132 L133 C149 H152 S154
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.8: quinol--cytochrome-c reductase.

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045275 respiratory chain complex III

External links

• PDB: RCSB:8ab7, PDBe:8ab7, PDBj:8ab7
• PDBsum: 8ab7
• PubMed: 36598500
• UniProt: Q6CI02