Structure of PDB 8a8u Chain E Binding Site BS01

Receptor Information

>8a8u Chain E (length=569) Species: 1773 (Mycobacterium tuberculosis)

SLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGE
PGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEE
RLKKVLKEINTRGDIILFIDELHTLVGAIDAASILKPKLARGELQTIGAT
TLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVS
ITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMVAEVDDEQ
IAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIR
RTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMG
EFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQE
IYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTYERMKQKVNDELK
KHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMALVLT
DAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTV
DVDNWDGEGPGEDAVFTFT

Ligand information

>8a8u Chain G (length=23) Species: 1773 (Mycobacterium tuberculosis)

AAAGAAAAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8a8u Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
• Resolution: 3.62 Å
• Binding residue (original residue number in PDB): Y261 F589 Y601 V602
• Binding residue (residue number reindexed from 1): Y94 F356 Y368 V369

Enzymatic activity

• Enzyme Commision number: 3.4.-.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042803 protein homodimerization activity
• GO:0044183 protein folding chaperone

Biological Process

• GO:0006457 protein folding

Cellular Component

• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:8a8u, PDBe:8a8u, PDBj:8a8u
• PDBsum: 8a8u
• PubMed: 36208775
• UniProt: P9WPC9|CLPC1_MYCTU ATP-dependent Clp protease ATP-binding subunit ClpC1 (Gene Name=clpC1)