Structure of PDB 7zjw Chain E Binding Site BS01

Receptor Information
>7zjw Chain E (length=519) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRRVNVNVGVLGHIDSGKTALARALSTLDLGFSCFSVPLPARLRSSLPGE
PLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVI
GQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIP
VAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFS
IKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPITSAMQG
DRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKA
KFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKD
HCPREQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGILLHGL
EDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFV
GLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPESKKILTPASEPSQHV
VLSLTFKRYVFDTHKRMVQ
Ligand information
>7zjw Chain F (length=90) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggaugauccucaguggucuggggugcaggcuucaaaccuguagcug
ucuagcgacagagugguucaauuccaccuuucgggcgcca
<<<<<<<.....<<<<......>>>>..<<<<<.......>>>>>..<<<
<<....>>>>>.<<<<.......>>>>..>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7zjw Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S98 H230 F232 V240 Q271 C289 E299 R300 H336 L433 D434 A435 K471 E497 N499
Binding residue
(residue number reindexed from 1)		S65 H197 F199 V207 Q238 C256 E266 R267 H303 L379 D380 A381 K417 E443 N445
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0035368 selenocysteine insertion sequence binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zjw, PDBe:7zjw, PDBj:7zjw
PDBsum7zjw
PubMed35709277
UniProtP57772|SELB_HUMAN Selenocysteine-specific elongation factor (Gene Name=EEFSEC)

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