Structure of PDB 7z42 Chain E Binding Site BS01

Receptor Information
>7z42 Chain E (length=743) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKIKRIPMKVK
DKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLA
KNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKW
NECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFMITS
KTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSPGMM
MGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCM
EGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELP
SFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYK
CHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIV
LKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPAHGPVKKMDYDAV
SGTHSWRTKRNILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQH
SMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEIGYIGS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution2.418 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 Y38 K365 L674
Binding residue
(residue number reindexed from 1)		H33 G34 T35 Y39 K356 L663
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8Y6

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