Structure of PDB 7yq6 Chain E Binding Site BS01

Receptor Information

>7yq6 Chain E (length=799) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSHRP
FEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPE
AKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELH
LCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD

Ligand information

>7yq6 Chain G (length=24) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cauuacgcaugagucuagauccgu

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yq6 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution	4.18 Å
Binding residue (original residue number in PDB)	Y477 R479 K484 R488 Q546 L552 R554
Binding residue (residue number reindexed from 1)	Y469 R471 K476 R480 Q538 L544 R546

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7yq6, PDBe:7yq6, PDBj:7yq6
PDBsum	7yq6
PubMed	36310231
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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