Structure of PDB 7yq5 Chain E Binding Site BS01

Receptor Information

>7yq5 Chain E (length=799) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSHRP
FEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPE
AKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELH
LCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD

Ligand information

>7yq5 Chain B (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NQHLCGSHLVEALYLVCGERGFFYT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yq5 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution	4.27 Å
Binding residue (original residue number in PDB)	N15 L37 F39 R65
Binding residue (residue number reindexed from 1)	N15 L37 F39 R65

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7yq5, PDBe:7yq5, PDBj:7yq5
PDBsum	7yq5
PubMed	36310231
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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