Structure of PDB 7yo1 Chain E Binding Site BS01

Receptor Information
>7yo1 Chain E (length=879) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTWMTSVKDWAGV
MISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQID
MAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSW
LGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFI
HLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLF
MVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITL
ESVSNFLKAFLHKARDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQG
SVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPK
IRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGL
STMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTV
CELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKYDSTG
MFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMP
LRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLR
AVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGVNIP
IITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSAT
YFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRV
AQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQ
CTKRYVITNPPYEFELVPTDLIFCLMQFD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7yo1 Chain E Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7yo1 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R514 S533 E535 S600
Binding residue
(residue number reindexed from 1)		R461 S480 E482 S531
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yo1, PDBe:7yo1, PDBj:7yo1
PDBsum7yo1
PubMed
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

[Back to BioLiP]