Structure of PDB 7yed Chain E Binding Site BS01

Receptor Information
>7yed Chain E (length=1058) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSEIQRHITEFISSWQNHPIVQVSADVENRKTAQLLHADTPRLVTWDAGL
CTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPFPEAAVSRIVVHTRWAS
NVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSVRGANPLMFRANVLHML
LEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPGPDAEKWYSIMYPTRMG
TPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSEWVDVFETSDALTVSIR
GRWMARLARMNINPTEIEWALTECAQGYVTVTSPYAPSVNRLMPYRISNA
ERQISQIIRVMNIGNNATVIQPVLQDISVLLQRISPLQIDPTIISNTMST
VSELSPASSILGKLRPSNSDFSSFRVALAGWLYNGVVTTVIDDSSYPKDG
GSVTSLENLWDFFILALALPLTTDPCAPVKAFMTLANMMVGFETIPMDNQ
IYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPILRQWAEIIHRYWPNPS
QIRYGTPNVFGSANLFTPPEVLLLPIDHQPANVTTPTLDFTNELTNWRAR
VCELMKNLVDNQRYQPGWTQSLVSSMRGTLGKLKLIKSMTPMYLQQLAPV
ELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTRQSRDTITQPALSLSTT
NTTVGVPLALDARAITVALLSGKYPPDLVTNVWYADAIYPMYADTEVFSN
LQRDVITCEAVQTLVTLVAQISETQYPVDRYLDWIPSLRASAATAATFAE
WVNTSMKTAFDLSDMLLEPLLSGDPRMTQLAIQYQQYNGRTFNVIPEMPG
SVIADCVQLTAEVFNHEYNLFGIARGDIIIGRVQSTHLWSPLAPPPDLVF
DRDTPGVHIFGRDCRISFGMNGAAPMIRDETGMMVPFEGNWIFPLALWQM
NTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYYDPRQYANAWNLTSAWL
EEITPTSIPSVPFMVPISSDHDISSAPAVQYIISTEYNDRSLFCTNSSSP
QTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVVDLYNVVTRYAYETPPI
TAVVMGVP
Ligand information
>7yed Chain M (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuaaaaauuuuaaaauaauu
.....................
Receptor-Ligand Complex Structure
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PDB7yed In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		L571 K580 T786 S788
Binding residue
(residue number reindexed from 1)		L354 K363 T569 S571
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yed, PDBe:7yed, PDBj:7yed
PDBsum7yed
PubMed36469786
UniProtC9E874

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