Structure of PDB 7wpq Chain E Binding Site BS01

Receptor Information

>7wpq Chain E (length=711) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNG
KRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKL
SGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGT
LTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLK
STSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEG
MVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGC
SCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWIC
SNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIET
VQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGD
LRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNG
NQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRF
SEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASY
AAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEEC
NEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMC
YCEDGFMHCTM

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7wpq Chain E Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wpq Structural basis of von Willebrand factor multimerization and tubular storage.
Resolution	3.267 Å
Binding residue (original residue number in PDB)	D47 N164 N166 F168 D172
Binding residue (residue number reindexed from 1)	D18 N135 N137 F139 D143
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7wpq, PDBe:7wpq, PDBj:7wpq
PDBsum	7wpq
PubMed	35148377
UniProt	P04275\|VWF_HUMAN von Willebrand factor (Gene Name=VWF)

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