Structure of PDB 7v07 Chain E Binding Site BS01

Receptor Information

>7v07 Chain E (length=517) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPA
ITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLV
FEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYT
QEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNT
ALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLV
DFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALP
ALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFG
MPWLSATTVRSVTHANALTVMGKAQIQEVKEQRISGLLVAVLVGLSILME
PILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKR
VKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLI
FRNVELQCLDADDAKAT

Ligand information

Ligand ID

FUC

InChI

InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1

InChIKey

SHZGCJCMOBCMKK-SXUWKVJYSA-N

SMILES

Software	SMILES
CACTVS 3.341	C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04	OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0	CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0	C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341	C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O

Formula

C6 H12 O5

Name

alpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose

PDB chain

7v07 Chain F Residue 6 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7v07 Architecture of the human erythrocyte ankyrin-1 complex.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	R432 Q434 A645
Binding residue (residue number reindexed from 1)	R62 Q64 A275
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005452	solute:inorganic anion antiporter activity
GO:0005515	protein binding
GO:0008509	monoatomic anion transmembrane transporter activity
GO:0015075	monoatomic ion transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015297	antiporter activity
GO:0030492	hemoglobin binding
GO:0030506	ankyrin binding
GO:0042803	protein homodimerization activity
GO:0043495	protein-membrane adaptor activity
GO:0140900	chloride:bicarbonate antiporter activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006820	monoatomic anion transport
GO:0006821	chloride transport
GO:0006873	intracellular monoatomic ion homeostasis
GO:0007596	blood coagulation
GO:0015701	bicarbonate transport
GO:0017121	plasma membrane phospholipid scrambling
GO:0035811	negative regulation of urine volume
GO:0045852	pH elevation
GO:0048821	erythrocyte development
GO:0051453	regulation of intracellular pH
GO:0055085	transmembrane transport
GO:0072659	protein localization to plasma membrane
GO:0098660	inorganic ion transmembrane transport
GO:1902476	chloride transmembrane transport
GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate

	Cellular Component
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0070062	extracellular exosome
GO:0072562	blood microparticle
GO:0170014	ankyrin-1 complex

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Cellular Component

External links

PDB	RCSB:7v07, PDBe:7v07, PDBj:7v07
PDBsum	7v07
PubMed	35835865
UniProt	P02730\|B3AT_HUMAN Band 3 anion transport protein (Gene Name=SLC4A1)

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