Structure of PDB 7uqj Chain E Binding Site BS01

Receptor Information
>7uqj Chain E (length=578) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGVDMNVNFDDIGGLDNYIDQLKEMVALPLLYPELYQNFNITPPRGVLFH
GPPGTGKTLMARALAASCSSDERKITFFMRKGADILSKWVGEAERQLRLL
FEEAKKHQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDNRG
QVIVIGATNRPDAVDPALRRPGRFDREFYFPLPDVKARFKILQIQTRKWS
SPLSTNFIDKLAFLTKGYGGADLRSLCTEAALISIQRSFPQIYRSNDKLL
VDPSKIKVKVSDFMLALKKIVPSSARSTGSSPQPLPELIKPLLADQLNNL
KNKLDYMLNIKDTTFQRNTSLLQNFIDYEEYSSYEFFESMAESQICKPRL
LINGPKGNGQQYVGAAILNYLEEFNVQNLDLASLVSESSRTIEAAVVQSF
MEAKKRQPSVVFIPNLDIWINTIPENVILVLSGLFRSLQSNEKILLLCLA
ENLDISEVKNGILSDFAFDKNIFQLHKPSKENITRYFSNLIELLKTKPSD
IPMKKRRVKPLPELQKVKELILTPEQIKKVSACLIEHCQNFTVSQLEDVH
SSVAKIIWKSKSAWDKTGTVDEIIKFLS
Ligand information
>7uqj Chain G (length=15) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KSTGGKAPRKQLASK
Receptor-Ligand Complex Structure
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PDB7uqj The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K491 W492 V493 G494 E532
Binding residue
(residue number reindexed from 1)		K88 W89 V90 G91 E129
Enzymatic activity
Enzyme Commision number 3.6.1.-
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0140674 ATP-dependent histone chaperone activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006261 DNA-templated DNA replication
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0034080 CENP-A containing chromatin assembly
GO:0045815 transcription initiation-coupled chromatin remodeling
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:2000219 positive regulation of invasive growth in response to glucose limitation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uqj, PDBe:7uqj, PDBj:7uqj
PDBsum7uqj
PubMed36592926
UniProtP40340|ATAD2_YEAST ATPase histone chaperone YTA7 (Gene Name=YTA7)

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