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Receptor Information

>7u6e Chain E (length=584) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN

>7u6e Chain B (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NQHLCGSHLVEALYLVCGERGFFYT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7u6e Activation of the human insulin receptor by non-insulin-related peptides
Resolution	3.0 Å
Binding residue (original residue number in PDB)	D12 R14 N15 L37 F39 K40 R65 R271
Binding residue (residue number reindexed from 1)	D12 R14 N15 L37 F39 K40 R65 R263

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

	Molecular Function
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

PDB	RCSB:7u6e, PDBe:7u6e, PDBj:7u6e
PDBsum	7u6e
PubMed	36171189
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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Structure of PDB 7u6e Chain E Binding Site BS01