Structure of PDB 7tjk Chain E Binding Site BS01

Receptor Information
>7tjk Chain E (length=437) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYF
NANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQ
VEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIK
LNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTIL
VMSRCGELMEDSCLRKRIIEEDDQFQNVAANFIHLIVQAFHSYTGNDIFA
LNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLLSIISKYL
LIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSLF
AIERLLAIFQAIFPIALREESLMKANIEVFQNLSELHTLKLIATTMNKNI
DYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIH
Ligand information
>7tjk Chain G (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tacagattttatgtttagatcttttatgcttgcttttcaaa
Receptor-Ligand Complex Structure
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PDB7tjk A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R360 R366 N440
Binding residue
(residue number reindexed from 1)		R329 R335 N399
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tjk, PDBe:7tjk, PDBj:7tjk
PDBsum7tjk
PubMed35217664
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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