Structure of PDB 7s7b Chain E Binding Site BS01

Receptor Information
>7s7b Chain E (length=924) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQR
EAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALS
NQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE
VAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEW
ICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT
AMQVLRDAGDLGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTK
LDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGG
LLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKD
FRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADP
LNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNS
EEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGR
LVKVKNEGDDFGWGVVVNFSKKSPLYVVEVLLRCSKESLKNSATEAAKPA
KPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQK
RFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETV
YTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSD
VIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENS
SEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMD
VVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTE
LENKFAEGITKIKRDIVFAASLYL
Ligand information
Receptor-Ligand Complex Structure
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PDB7s7b Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Resolution4.06 Å
Binding residue
(original residue number in PDB)		K192 T228 E230 I231 R233 E261 R262 S395 K396 T482 E483 F504 D505 G506 F509 S881 S882 N917 S919 R995 R999 E1002 Q1006
Binding residue
(residue number reindexed from 1)		K97 T133 E135 I136 R138 E166 R167 S287 K288 T374 E375 F396 D397 G398 F401 S763 S764 N799 S801 R877 R881 E884 Q888
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0006974 DNA damage response
GO:0008380 RNA splicing
GO:0016076 snRNA catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031499 TRAMP complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s7b, PDBe:7s7b, PDBj:7s7b
PDBsum7s7b
PubMed35688134
UniProtP42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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