Structure of PDB 7rpx Chain E Binding Site BS01

Receptor Information
>7rpx Chain E (length=590) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLW
PDFLGYPELGIGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRLKS
KQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGL
LKKADPLEAKFLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERA
YNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAERLSNPEEILKK
MGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYI
EGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVFLF
DLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFF
YRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVV
VGGFYGKGKRGGKISSLLMAAYNPKTDSFESVCKVASGFSDEQLDELQKK
LMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVE
KDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rpx Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		S18 E58 G60 G62 E63 K64 F65 R240 D262 E264 R281 F324
Binding residue
(residue number reindexed from 1)		S18 E58 G60 G62 E63 K64 F65 R240 D262 E264 R281 F324
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7rpx, PDBe:7rpx, PDBj:7rpx
PDBsum7rpx
PubMed34838188
UniProtQ980T8|DNLI_SACS2 DNA ligase (Gene Name=lig)

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