Structure of PDB 7r6v Chain E Binding Site BS01

Receptor Information
>7r6v Chain E (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADR
KHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFY
LSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGK
KIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQ
PQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTL
YLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r6v Human EXOG possesses strong AP hydrolysis activity
Resolution2.16 Å
Binding residue
(original residue number in PDB)		R109 S137 R138 H140 G145 K148 F168 N171 S172 N176 L311
Binding residue
(residue number reindexed from 1)		R50 S78 R79 H81 G86 K89 F109 N112 S113 N117 L252
Enzymatic activity
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7r6v, PDBe:7r6v, PDBj:7r6v
PDBsum7r6v
PubMed
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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