Structure of PDB 7q41 Chain E Binding Site BS01
Receptor Information
>7q41 Chain E (length=368) Species:
9606
(Homo sapiens) [
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TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT
VEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH
ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGS
SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC
GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC
QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK
IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG
QKITRVACGSSHSVAWTT
Ligand information
>7q41 Chain F (length=7) Species:
9606
(Homo sapiens) [
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DEDKDED
Receptor-Ligand Complex Structure
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PDB
7q41
Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of ubiquitin-protein ligase E3A (E6AP)
Resolution
3.01478 Å
Binding residue
(original residue number in PDB)
K2979 R3161 A3214 Y3234 D3285 H3286 S3318 S3319
Binding residue
(residue number reindexed from 1)
K21 R203 A256 Y276 D327 H328 S360 S361
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
External links
PDB
RCSB:7q41
,
PDBe:7q41
,
PDBj:7q41
PDBsum
7q41
PubMed
UniProt
O95714
|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)
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