Structure of PDB 7pe8 Chain E Binding Site BS01

Receptor Information
>7pe8 Chain E (length=1115) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSE
EKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLK
VDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGN
DGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRIN
EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLK
EDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIR
RGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAK
TILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRAT
ILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALN
CLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQILKDTEEALLINLR
DSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKP
SSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQW
LNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQ
CLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYAT
KHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKAN
LHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHR
EYNSKYVDLIEEQLNEALTTYRKPQRPHVYLPIHLYGQLVHHKTGCHLLE
VQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEEN
VIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSR
KHLWPVVPDYIGLALPVDINDIFQVKDIPYFQTKSFHLLRQQMSLTEIMN
TGLQEHTDDNCLYCVCIEILGFQPSNQMCRILLRKEVLRLVINLSSSVST
KCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQD
VQFLQMHEEAEAVLA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7pe8 Chain E Residue 4801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pe8 Regulation of human mTOR complexes by DEPTOR.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H1515 C1520 C1523 C1651
Binding residue
(residue number reindexed from 1)		H1006 C1011 C1014 C1072
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007010 cytoskeleton organization
GO:0009792 embryo development ending in birth or egg hatching
GO:0010468 regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030307 positive regulation of cell growth
GO:0030838 positive regulation of actin filament polymerization
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032956 regulation of actin cytoskeleton organization
GO:0038203 TORC2 signaling
GO:0043066 negative regulation of apoptotic process
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0031932 TORC2 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pe8, PDBe:7pe8, PDBj:7pe8
PDBsum7pe8
PubMed34519268
UniProtQ6R327|RICTR_HUMAN Rapamycin-insensitive companion of mTOR (Gene Name=RICTOR)

[Back to BioLiP]