Structure of PDB 7p7e Chain E Binding Site BS01

Receptor Information

>7p7e Chain E (length=156) Species: 469008 (Escherichia coli BL21(DE3))

AFELSAAEREAIEHEMHHYEDPRAASIEALKIVQKQRGWVPDGAIHAIAD
VLGIPASDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHINGYQGIQAALE
KKLNIKPGQTTFDGRFTLLPTCCLGNCDKGPNMMIDEDTHAHLTPEAIPE
LLERYK

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 7p7e Chain E Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7p7e A universal coupling mechanism of respiratory complex I.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): C92 V96 C97 C133 L134 G135 N136 C137
• Binding residue (residue number reindexed from 1): C82 V86 C87 C123 L124 G125 N126 C127
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.-

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0030964 NADH dehydrogenase complex
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7p7e, PDBe:7p7e, PDBj:7p7e
• PDBsum: 7p7e
• PubMed: 36104567
• UniProt: P0AFD1|NUOE_ECOLI NADH-quinone oxidoreductase subunit E (Gene Name=nuoE)