Structure of PDB 7oqc Chain E Binding Site BS01

Receptor Information
>7oqc Chain E (length=544) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDKYTALIHDENFSTLTLNVSRYPKSLAYWEKLLNYIVKASAPICKSTEP
QLLKLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSHKIFQRGLQA
FNQRSLLLWTSYLKFCNNVISHQKQLFKKYETAEEYVGLHFFSGEFWDLY
LEQISSRCTSSKKYWNVLRKILEIPLHSFSKFYALWLQRIDDIMDLKQLS
QLTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQYQVLE
IYSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQ
RALLPLAHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKL
LYSVICKLNEYVLLRNLLEKIESSYSDNVENVDDFEIFWDYLQFKTFCQN
SLYSSRYSDSQSNGLLNKELFDKVWKRLSCKEKKSGQEILLNNLVQFYSK
DTVEFVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFDTSRSYLDKRQY
IVRKIWPQIDKKFAQSVLPSLTEFCESYFPEEMDTLEEMFTEEP
Ligand information
>7oqc Chain 1 (length=558) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auacuuaccuuaagauaucagaggagaguccuacugaucaaacaugcgcu
uccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguuca
uugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaa
ggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucc
cuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuug
uuucuucugccuggagaaguuugacaccaaauucaaauugguguuagggg
agcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuac
uuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuu
aaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguag
uuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuau
gggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuu
ugauuuau
...........<<<<.<<<<<<<<<...>>>>.>>>>><<<<<<<<<.<<
<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<.......>>>>>
.>>>.......>>>>>.>>>>>>>>.....................>>>>
>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<
<..<<<<<<<..>>>>>>>...>>>.>.>>>>>>>..>>>>>>>((....
...<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>
><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<
..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<..
..>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>
>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>
>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>........
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oqc Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		Q95 Q123 Q125 K128 C158 M194 D195 L196 G220 R221 K222 G223
Binding residue
(residue number reindexed from 1)		Q95 Q123 Q125 K128 C158 M194 D195 L196 G220 R221 K222 G223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0030627 pre-mRNA 5'-splice site binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oqc, PDBe:7oqc, PDBj:7oqc
PDBsum7oqc
PubMed34349264
UniProtQ03776|PRP42_YEAST U1 small nuclear ribonucleoprotein component PRP42 (Gene Name=PRP42)

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