Structure of PDB 7onu Chain E Binding Site BS01

Receptor Information
>7onu Chain E (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAW
VAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYS
LLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAW
NLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLY
PGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLSPEE
YECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVA
KMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQ
KQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQ
RLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDL
VERCSCEVPTKWLCLHQ
Ligand information
>7onu Chain T (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gagguaaaauggcugagaagcauuggacuguaaaucuaaagacagggguu
aggccucuuuuuacca
..<<<<<<<..<<<....>>>.<<<<<.......>>>>>....<<<<<..
...>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB7onu Structural basis of RNA processing by human mitochondrial RNase P.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G150 Y183 R211 L411 N412 K415 P418 R445 H447 R450 D474 D499 L500 R502 D503
Binding residue
(residue number reindexed from 1)		G36 Y69 R97 L297 N298 K301 P304 R331 H333 R336 D360 D385 L386 R388 D389
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0004526 ribonuclease P activity
GO:0046872 metal ion binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7onu, PDBe:7onu, PDBj:7onu
PDBsum7onu
PubMed34489609
UniProtO15091|MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (Gene Name=PRORP)

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