Structure of PDB 7oi7 Chain E Binding Site BS01

Receptor Information
>7oi7 Chain E (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPGS
FRVGLIALKLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMAT
LSVGGKTVSRFRKATSILEFYRELGLPPKQTVKIFNITDNAAIKPGTPLY
AAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKTGDIGRVWPGTKMPGKMGN
IYRTEYGLKVWRINTKHNIIYVNGSVPGHKNCLVKVKDSKLPAYKDLGKN
LPFPTYFPDGDEEELPEDLYDENVCQPGAPSITFA
Ligand information
>7oi7 Chain A (length=1054) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacu
uuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaa
gcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacag
gguu
<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>..>>>.>>
..<<<.<<<.................>>>.>>><<<<<...<<<....>>
>.>>>>>.<<<.<............>.>>>........<<<<.......>
>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oi7 A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
W48 W49 K62 V65 D69 K103 M106 V118 V152 S153 R154 F155 R156 K157 I161 Y165 Q174 V176 K177 I178 I211 G212 K213 G214 F215 G217 K220 R221 W222 T245 I248 G249 R250 V251 W252 P253 G254 M257 K260 N263 I264 Y265 R266 E268 Y269 G287 S288 V289 P290 G291 H292 K293 N294 K298 K300 K303 L304 P305
Binding residue
(residue number reindexed from 1)
W4 W5 K18 V21 D25 K59 M62 V74 V108 S109 R110 F111 R112 K113 I117 Y121 Q130 V132 K133 I134 I167 G168 K169 G170 F171 G173 K176 R177 W178 T182 I185 G186 R187 V188 W189 P190 G191 M194 K197 N200 I201 Y202 R203 E205 Y206 G224 S225 V226 P227 G228 H229 K230 N231 K235 K237 K240 L241 P242
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7oi7, PDBe:7oi7, PDBj:7oi7
PDBsum7oi7
PubMed34315873
UniProtP09001|RM03_HUMAN Large ribosomal subunit protein uL3m (Gene Name=MRPL3)

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