Structure of PDB 7ods Chain E Binding Site BS01

Receptor Information
>7ods Chain E (length=305) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPG
SFRVGLIALKLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMA
TLSVGGKTVSRFRKATSILEFYRELGLPPKQTVKIFNITDNAAIKPGTPL
YAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPATHGQTKTHRRPGAV
ATGDIGRVWPGTKMPGKMGNIYRTEYGLKVWRINTKHNIIYVNGSVPGHK
NCLVKVKDSKLPAYKDLGKNLPFPTYFPDGDEEELPEDLYDENVCQPGAP
SITFA
Ligand information
>7ods Chain A (length=1445) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaa
aaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuau
cacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucucc
uccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcc
caauaucuacaaucaaccaacaagucauuauuacccucacugucaaccca
acacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggc
aaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccagu
auuagaggcaccgccugcuggcuccacgaggguucagcugucucuuacuu
uuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaa
gacgagaagacccuauggagcuuuaauuuauuaaugcaaacagaaaccug
cauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgag
caguacaugcuaagacuucaccagucaaagcgaacacucaauugauccaa
uaacuugaccaacggaacaaguuacccuagggaagcgcaauccuauucua
gaguccauaucaacaauaggguuuacgaccucguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
caaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaa
agcgccuucccccguaaaugauaucaucucaacuuaguauacccacccca
cccaagaacaggguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>...<<<......>>>....<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
..................>...>>>>>>........>>>>>>...<<<<<
......>>>>>.........>>>>>><......<<..<<<....>>><<<
<..<<<<........<<<<<..............>>>>>......<<<..
.<<<<.......................>>>>.......>>>.....<<.
.....>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........
.......<<<<<<..<<<.........>>>...<<<<<<...........
..>>>>>>....<<<....>>>....>>.>>>>........>>.>>>>>>
>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<
<<.<<<....<<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>
>>>>>>>>>>>..<<<<((((.>>>><<<<<<...........>>>>>>.
.<<.....<<<..<<<<.....>>>>..>>>.....>>.........<<<
....>>>............>>>>..>>>>>>>......<<<<<<<<<...
<<.......>>...>>>>>>>>>.....)))).<<<<<..<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.....>>>>>.....<<<<<<<....>>>.>>>>...>>>..>>>.>>..
.<.<<<.<<<.................>>>.>>><<<<<...<<<....>
>>.>>>>>......<<<................>>>...>.........<
<<<.......>>>>...............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ods Stepwise maturation of the peptidyl transferase region of human mitoribosomes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
W48 W49 V65 D69 M106 V118 K141 S153 F155 R156 I161 Y165 V176 K177 T210 I211 G212 K213 G214 F215 G217 M219 R221 F224 K225 G226 T230 H231 G232 Q233 K235 T236 H237 R238 R239 P240 G241 A242 V243 A244 T245 G246 D247 I248 G249 R250 V251 W252 P253 G254 T255 M257 P258 K260 I264 Y265 R266 E268 Y269 L271 S288 V289 P290 G291 H292 K293 N294 K298 K303 L304
Binding residue
(residue number reindexed from 1)
W5 W6 V22 D26 M63 V75 K98 S110 F112 R113 I118 Y122 V133 K134 T167 I168 G169 K170 G171 F172 G174 M176 R178 F181 K182 G183 T187 H188 G189 Q190 K192 T193 H194 R195 R196 P197 G198 A199 V200 A201 T202 G203 D204 I205 G206 R207 V208 W209 P210 G211 T212 M214 P215 K217 I221 Y222 R223 E225 Y226 L228 S245 V246 P247 G248 H249 K250 N251 K255 K260 L261
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7ods, PDBe:7ods, PDBj:7ods
PDBsum7ods
PubMed34135320
UniProtP09001|RM03_HUMAN Large ribosomal subunit protein uL3m (Gene Name=MRPL3)

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