Structure of PDB 7mqs Chain E Binding Site BS01

Receptor Information
>7mqs Chain E (length=806) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEE
CGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEK
TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLK
IRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL
TITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE
NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDI
DPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSD
IIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER
QAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRE
EHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSAR
TMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD
EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFY
VTDYLD
Ligand information
>7mqs Chain C (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCHSLQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		D535 P537 P549 G550 W551 L552
Binding residue
(residue number reindexed from 1)		D501 P503 P515 G516 W517 L518
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum7mqs
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

[Back to BioLiP]