Structure of PDB 7let Chain E Binding Site BS01
Receptor Information
>7let Chain E (length=423) Species:
10090
(Mus musculus) [
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NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYFS
Ligand information
>7let Chain B (length=8) Species:
9606
(Homo sapiens) [
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QRKRQKLM
Receptor-Ligand Complex Structure
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PDB
7let
Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
R101 K102 S105 E107 W142 N146 A148 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 W273
Binding residue
(residue number reindexed from 1)
R27 K28 S31 E33 W68 N72 A74 S75 G76 T81 Q107 W110 N114 G117 D118 N154 W157 W199
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7let
,
PDBe:7let
,
PDBj:7let
PDBsum
7let
PubMed
35260573
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
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