Structure of PDB 7kd6 Chain E Binding Site BS01
Receptor Information
>7kd6 Chain E (length=286) Species:
9606
(Homo sapiens) [
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EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLI
MITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELG
LYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEEC
GDICCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQ
PDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKN
CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
Ligand information
>7kd6 Chain F (length=15) Species:
9606
(Homo sapiens) [
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TFEDYLHNVVFVPRP
Receptor-Ligand Complex Structure
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PDB
7kd6
Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
R14 L36 L37 F64 F88 F89 F96 R118
Binding residue
(residue number reindexed from 1)
R9 L31 L32 F59 F83 F84 F91 R113
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:7kd6
,
PDBe:7kd6
,
PDBj:7kd6
PDBsum
7kd6
PubMed
36181268
UniProt
P06213
|INSR_HUMAN Insulin receptor (Gene Name=INSR)
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