Structure of PDB 7k98 Chain E Binding Site BS01

Receptor Information
>7k98 Chain E (length=836) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQSNAMRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGP
VDGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDL
VVVALPGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPP
GAAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFV
DPASNSRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQ
RRLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGE
TAVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEA
AIWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAG
GEVSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQ
IGAVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAP
AGRGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRR
MTTRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQP
TEQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWG
PGRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSV
GHAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQD
VSLVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFA
LRFRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG
Ligand information
>7k98 Chain C (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccagguagcucagucgguaugagcguccgccugaaaagcggaaggucg
gcgguucgaucccgccccuggccacca
<<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7k98 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		P738 Y739 P740 A741 V742 Q744 D745 S747 D778 F780 Q784 T793 T804 L805 T806 E807 R814 R830
Binding residue
(residue number reindexed from 1)		P743 Y744 P745 A746 V747 Q749 D750 S752 D783 F785 Q789 T798 T809 L810 T811 E812 R819 R835
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7k98, PDBe:7k98, PDBj:7k98
PDBsum7k98
PubMed33885823
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

[Back to BioLiP]