Structure of PDB 7jl2 Chain E Binding Site BS01

Receptor Information
>7jl2 Chain E (length=662) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS
EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVV
KSCDIIISTAQILENSLLNLAGVQLSDFSLIIIDECHHTNKEAVYNNIMR
HYLMQKLKNNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANL
DAFTIKTVKENLDQLKNQIQEPCKKFAIADREDPFKEKLLEIMTRIQTYC
QMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQIND
TIRMIDAYTHLETFYNEEKDKKFAVIEETDRFLMTLFFENNKMLKRLAEN
PEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEK
FAEVGVKAHHLIGAGSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEE
GLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIERE
TVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAK
HYNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVREKQ
INGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVE
LPITFPNLDYSE
Ligand information
>7jl2 Chain X (length=44) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacugacugacugaagacugacugacugaagacugacugacuga
............................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jl2 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		K450 E451 Q580 R843 H927 K1002 W1003
Binding residue
(residue number reindexed from 1)		K141 E142 Q265 R499 H582 K647 W648
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7jl2, PDBe:7jl2, PDBj:7jl2
PDBsum7jl2
PubMed33373584
UniProtQ9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)

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